Technology

Technology Advantage

InstaStrip technology greatly enhanced the sensitivity and readability of the lateral flow assays, enabling the fast and clear detection of low ng/mL drugs of abuse without the need of any instrument by lay users. Compared to traditional lateral flow products, InstaStrip technology features the drastic contrast between the negative and positive readouts, and the sharp signal transition across the cutoff concentration (Below Figure), and is ideal for field or at-home use for detecting drugs of abuse with extremely high sensitivity at or even below 1 ng/mL.

Video Demonstration

Publications

Zhao JY, Uddin M, Unsihuay D, Butler W, Xia TW, Xu JZ, Wang S, Sheng X, Jannetto PJ, Wang P, Xia X, Rapid and Sensitive Detection of Fentanyl and Its Analogs by a Novel Chemiluminescence Immunoassay, Clin Chem 2024. May 17:Hvae071

2023 Defense TechConnect Innovation Summit and Expo Poster Presentation

Chen H, Li Z, Feng S, Richard-Greenblatt M, Hutson E, Andrianus S, Glaser LJ, Rodino KG, Qian J, Jayaraman D, Collman RG, Glascock A, Bushman FD, Lee JS, Cherry S, Fausto A, Weiss SR, Koo H, Corby PM, O’Doherty U, Garfall AL, Vogl DT, Stadtmauer EA, Wang P: Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking. Clin Chem 2021, 68(1): 230-239.

Li Z., Chen H., Feng S., Liu K. and Wang P.: Development and Clinical Validation of a Sensitive Lateral Flow Assay for Rapid Urine Fentanyl Screening in the Emergency Department. Clin Chem 2020, 66(2): 324-332.

Li Z and Wang P: Point of Care Drugs of Abuse Testing in the Opioid Epidemic. Arch Pathol Lab Med 2020, 144(11): 1325-1334.

Chen H., Li Z., Zhang L., Sawaya P., Shi J., Wang P.: Quantitation of Femtomolar Protein Biomarkers Using a Simple Microbubbling Digital Assay via Bright-field Smartphone Imaging. Angewandte Chemie International Edition 2019, 58(39): 2-9.

Li Z., Chen H. and Wang P.: Lateral Flow Assay Ruler for Quantitative and Rapid Point-of-care Testing. Analyst 2019, 144(10): 3314-3322.

Chen H., Liu K., Li Z. and Wang P.: Point-of-care Testing for Infectious Diseases. Clinica Chimica Acta 2019, 493: 138-147.

2023 Defense TechConnect, Innovation Summit and Expo Poster Presentation

Wang P and Kricka LJ: Current and Emerging Trends in Point-of-care Technology and Strategies for Clinical Validation and Implementation. Clin Chem 2018, 64(10): 1439-1452.